SEC24B

Across TCGA patient cohorts, SEC24B mutation is significantly associated with the RNA expression of many other genes, with 2,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC24B-associated genes across cancer lineages are SLC25A33, RANBP3, and RAD51. Each is linked with SEC24B in more than 3 cancer types. Because this analysis shows association rather than direction, both SEC24B-to-partner and partner-to-SEC24B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A33 grouped by SEC24B-low versus SEC24B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24B→partner) and Y-score (partner→SEC24B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A33 →	+0.474	+1.660	<.001	.003	3	3
UCEC	RANBP3 →	+0.351	+2.780	<.001	<.001	3	3
UCEC	RAD51 →	+0.653	+2.283	<.001	<.001	3	3
UCEC	COASY →	+0.412	+1.776	<.001	<.001	3	3
UCEC	SLC22A17 →	-0.630	-1.704	.006	.007	3	3
UCEC	CRYBB2P1 →	+0.563	+2.606	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,088 associations by consensus.

SLC25A33 by SEC24B expression — UCEC

Explore this box plot interactively →