SEC24A

Across TCGA pan-cancer cohorts, SEC24A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEC24A data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEC24A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEC24A expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where SEC24A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.637	1.000	.003	24	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
LSCC	DFS	Median	II,III,IV	0.546	0.824	.020	7	view →
GBM	OS	Quartile	All	0.365	0.630	.025	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEC24A–CCRCC (OS)

Open the CCRCC breakdown →