SEC23IP

Across TCGA patient cohorts, SEC23IP mutation is significantly associated with the RNA expression of many other genes, with 4,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC23IP-associated genes across cancer lineages are RNU1-17P, MIR2278, and MIR4293. Each is linked with SEC23IP in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC23IP-to-partner and partner-to-SEC23IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by SEC23IP-low versus SEC23IP-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23IP→partner) and Y-score (partner→SEC23IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.372	+4.688	<.001	.001	3	2
SKCM	MIR2278 →	+0.346	+3.454	<.001	.006	3	2
BRCA	MIR4293 →	+0.222	+8.057	<.001	.005	3	2
LUAD	VDAC1P3 →	+0.104	+3.102	.001	.004	3	2
LUAD	BCAS2P1 →	+0.521	+3.298	<.001	.002	3	2
LUAD	RN7SL774P →	+0.163	+2.908	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

RNU1-17P by SEC23IP expression — CESC

Explore this box plot interactively →