SEC23A-AS1

Across TCGA pan-cancer cohorts, SEC23A-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SEC23A-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SEC23A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC23A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

UCS, TGCT, and LUAD are the cancer types where SEC23A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	IV	0.230	0.767	.009	42	view →
TGCT	DFS	Tertile	II,III,IV	0.523	0.952	.006	36	view →
LUAD	OS	Quartile	II,III,IV	0.692	0.498	.007	24	view →
PAAD	OS	Tertile	All	0.659	0.243	.001	21	view →
LUSC	DFS	Quartile	III,IV	0.125	0.647	.006	18	view →
LAML	DFS	Quartile	All	0.380	0.644	.008	18	view →
KIRC	DFS	Quartile	II,III,IV	0.709	0.849	.004	16	view →
STAD	DFS	Quartile	All	0.779	0.426	.008	15	view →
OV	OS	Tertile	II,III,IV	0.884	0.772	.019	14	view →
THCA	DFS	Median	III,IV	0.630	0.876	.010	14	view →
UCEC	OS	Tertile	All	0.786	0.634	.014	14	view →
DLBC	DFS	Tertile	III,IV	0.196	0.827	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SEC23A-AS1–UCS (DFS)

Open the UCS breakdown →