SEC22C

Across TCGA patient cohorts, SEC22C mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC22C-associated genes across cancer lineages are RNU6-451P, RPL34P8, and UBFD1P1. Each is linked with SEC22C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC22C-to-partner and partner-to-SEC22C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-451P grouped by SEC22C-low versus SEC22C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22C→partner) and Y-score (partner→SEC22C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-451P →	+0.512	+2.801	<.001	<.001	3	2
COAD	RPL34P8 →	+0.213	+4.993	.006	.002	3	2
COAD	UBFD1P1 →	+0.132	+5.721	<.001	.001	3	2
SKCM	RPS23P5 →	+0.108	+4.159	<.001	.002	3	2
SKCM	RNU6-328P →	+0.230	+4.199	<.001	.009	3	2
UCEC	C11orf40 →	+0.118	+2.467	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

RNU6-451P by SEC22C expression — UCEC

Explore this box plot interactively →