SEC22B

Across TCGA patient cohorts, SEC22B protein abundance is significantly associated with the RNA expression of many other genes, with 10,502 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SEC22B-associated genes across cancer lineages are HDAC5, UCKL1, and MAPK12. Each is linked with SEC22B in more than 3 cancer types. Because this analysis shows association rather than direction, both SEC22B-to-partner and partner-to-SEC22B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC22B versus HDAC5 in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22B→partner) and Y-score (partner→SEC22B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDAC5 →	-0.457	-0.335	.004	.002	3	4
COAD	UCKL1 →	-0.523	-0.149	.001	<.001	3	4
CCRCC	MAPK12 →	-0.804	-0.215	<.001	.004	3	4
UCEC	FIS1 →	-0.963	-0.304	.003	.007	3	4
CCRCC	IL17RD →	-1.104	-0.306	<.001	<.001	3	4
HNSC	XBP1 →	+1.021	+0.332	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,502 associations by consensus.

SEC22B vs HDAC5 — BRCA

Explore this scatter interactively →