SEC22B

Across TCGA pan-cancer cohorts, SEC22B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SEC22B data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SEC22B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC22B expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

CESC, LGG, and HNSC are the cancer types where SEC22B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	III,IV	0.189	0.775	<.001	62	view →
LGG	DFS	Median	All	0.648	0.835	<.001	54	view →
HNSC	OS	Quartile	III,IV	0.499	0.797	.008	23	view →
SCLC	DFS	Tertile	All	0.659	1.000	.021	22	view →
KIRP	DFS	Tertile	All	0.872	0.950	.018	22	view →
LUSC	DFS	Tertile	II,III,IV	0.213	0.535	.002	22	view →
KICH	OS	Median	II,III,IV	0.648	0.958	.006	21	view →
UVM	DFS	Quartile	All	0.392	0.832	.012	19	view →
SARC	OS	Median	All	0.774	0.930	.002	17	view →
OV	DFS	Tertile	All	0.432	0.342	.010	16	view →
KIRC	DFS	Quartile	All	0.856	0.676	.005	16	view →
THCA	OS	Quartile	II,III,IV	0.614	0.849	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SEC22B–CESC (DFS)

Open the CESC breakdown →