SEC22A

Across TCGA patient cohorts, SEC22A mutation is significantly associated with the RNA expression of many other genes, with 1,584 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC22A-associated genes across cancer lineages are MIR6780A, TRAJ22, and EIF3JP1. Each is linked with SEC22A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC22A-to-partner and partner-to-SEC22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780A grouped by SEC22A-low versus SEC22A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22A→partner) and Y-score (partner→SEC22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6780A →	+0.479	+2.801	<.001	.001	3	2
UCEC	TRAJ22 →	+0.584	+2.010	.003	.008	3	2
LUAD	EIF3JP1 →	+0.200	+3.896	<.001	.002	3	2
LUSC	RNU6-884P →	+0.474	+3.712	.007	.007	3	1
LUSC	RNU6-1322P →	+0.237	+3.408	.007	.009	3	1
LUSC	RNU6-378P →	+0.392	+3.265	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,584 associations by consensus.

MIR6780A by SEC22A expression — UCEC

Explore this box plot interactively →