SEC22A

Across TCGA cell cohorts, SEC22A mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SEC22A-associated genes across cancer lineages are OR2AK2, PTH2, and FEZF2. Each is linked with SEC22A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC22A-to-partner and partner-to-SEC22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AK2 grouped by SEC22A-low versus SEC22A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22A→partner) and Y-score (partner→SEC22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2AK2 →	+0.062	+4.029	<.001	.009	3	1
CNS	PTH2 →	+0.090	+4.321	<.001	.009	3	1
CNS	FEZF2 →	+0.121	+4.169	<.001	.008	3	1
CNS	TMEM174 →	+0.083	+4.472	<.001	.004	3	1
CNS	UCMA →	+0.207	+4.754	<.001	.005	3	1
CNS	OR4D6 →	+0.107	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR2AK2 by SEC22A expression — OVARY

Explore this box plot interactively →