SEC16B

Across TCGA patient cohorts, SEC16B mutation is significantly associated with the RNA expression of many other genes, with 4,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC16B-associated genes across cancer lineages are GINS3, DRG1, and OR2A9P. Each is linked with SEC16B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC16B-to-partner and partner-to-SEC16B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS3 grouped by SEC16B-low versus SEC16B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC16B→partner) and Y-score (partner→SEC16B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.468	+1.606	<.001	<.001	3	3
UCEC	DRG1 →	+0.325	+3.616	<.001	<.001	3	3
UCEC	OR2A9P →	-0.147	-2.147	.004	<.001	3	3
UCEC	PDXP →	+0.277	+2.606	.005	<.001	3	3
UCEC	MPV17L2 →	+0.327	+1.450	<.001	<.001	3	3
UCEC	HMBS →	+0.368	+2.501	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,129 associations by consensus.

GINS3 by SEC16B expression — UCEC

Explore this box plot interactively →