SEC16B

Across TCGA pan-cancer cohorts, SEC16B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SEC16B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEC16B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC16B is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where SEC16B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC16B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.227	<.001	12	view →
HNSC	Male	II,III,IV	+0.126	<.001	12	view →
COAD	All	IV	+0.145	.003	8	view →
KICH	Female	All	−0.156	<.001	6	view →
BRCA	All	III,IV	−0.145	<.001	6	view →
LIHC	Male	All	+0.374	.009	2	view →
BLCA	All	All	+0.089	.048	2	view →
READ	All	All	+0.318	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SEC16B–KIRC

Open the KIRC breakdown →