SEC16B

Across TCGA cell cohorts, SEC16B mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC16B-associated genes across cancer lineages are VWC2L, ADAM7, and F11. Each is linked with SEC16B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC16B-to-partner and partner-to-SEC16B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by SEC16B-low versus SEC16B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC16B→partner) and Y-score (partner→SEC16B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.009	+2.661	<.001	.005	3	3
BLOOD_Leukemia	ADAM7 →	+0.018	+2.922	<.001	.009	3	2
BLOOD_Leukemia	F11 →	+0.063	+2.855	<.001	.002	3	2
BLOOD_Myeloma	SCYGR2 →	+0.140	+4.807	<.001	.006	3	1
LUNG_SCLC	IL3 →	+0.035	+4.029	<.001	<.001	3	1
LUNG_SCLC	MRAP →	+0.066	+3.256	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

VWC2L by SEC16B expression — BLOOD_Leukemia

Explore this box plot interactively →