SEC14L5

Across TCGA patient cohorts, SEC14L5 mutation is significantly associated with the RNA expression of many other genes, with 3,502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L5-associated genes across cancer lineages are E2F6P2, RFKP1, and MSANTD3. Each is linked with SEC14L5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC14L5-to-partner and partner-to-SEC14L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P2 grouped by SEC14L5-low versus SEC14L5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L5→partner) and Y-score (partner→SEC14L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	E2F6P2 →	+0.058	+5.303	<.001	.006	3	3
SARC	RFKP1 →	+0.086	+4.620	.001	.007	3	3
UCEC	MSANTD3 →	+0.646	+3.711	<.001	<.001	3	3
UCEC	ZNF329 →	+0.387	+2.447	.007	.001	3	3
UCEC	ARHGAP19 →	+0.583	+2.595	<.001	<.001	3	3
UCEC	PINCR →	+0.307	+1.922	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,502 associations by consensus.

E2F6P2 by SEC14L5 expression — HNSC

Explore this box plot interactively →