SEC14L2

Across TCGA cell cohorts, SEC14L2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC14L2-associated genes across cancer lineages are ZIM2, OR10W1, and CA5A. Each is linked with SEC14L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L2-to-partner and partner-to-SEC14L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIM2 grouped by SEC14L2-low versus SEC14L2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L2→partner) and Y-score (partner→SEC14L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZIM2 →	+0.046	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	CA5A →	+0.447	+3.578	<.001	.006	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.017	+3.977	<.001	.001	3	1
BLOOD_Lymphoma	MAGEL2 →	+0.022	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ZIM2 by SEC14L2 expression — OESOPHAGUS

Explore this box plot interactively →