SEC13

Across TCGA pan-cancer cohorts, SEC13 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEC13 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEC13 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC13 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where SEC13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.339	0.836	.002	26	view →
LSCC	DFS	Tertile	III,IV	0.407	1.000	.002	22	view →
UCEC	DFS	Median	All	0.943	0.770	.004	8	view →
PDAC	OS	Tertile	IV	0.916	0.231	.024	6	view →
GBM	OS	Quartile	All	0.696	0.891	.024	5	view →
LUAD	OS	Median	All	0.669	0.854	.024	4	view →
HNSC	DFS	Quartile	III,IV	0.911	0.691	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEC13–CCRCC (DFS)

Open the CCRCC breakdown →