SEC11C

Across TCGA pan-cancer cohorts, SEC11C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SEC11C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SEC11C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SEC11C is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where SEC11C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC11C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.096	<.001	9	view →
LSCC	Female	All	+1.406	<.001	8	view →
COAD	All	III,IV	−0.370	<.001	8	view →
PDAC	Female	All	−2.160	<.001	7	view →
CCRCC	Male	All	+0.287	.003	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SEC11C–LUAD

Open the LUAD breakdown →