SEC11C

Across TCGA pan-cancer cohorts, SEC11C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SEC11C data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SEC11C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC11C expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

UVM, MESO, and HNSC are the cancer types where SEC11C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.285	0.792	<.001	81	view →
MESO	OS	Tertile	All	0.542	0.263	.001	75	view →
HNSC	OS	Median	All	0.831	0.706	<.001	38	view →
GBM	DFS	Median	All	0.192	0.320	.003	36	view →
LGG	DFS	Tertile	All	0.783	0.888	<.001	29	view →
COAD	OS	Median	IV	0.939	0.321	<.001	29	view →
LUAD	OS	Median	II,III,IV	0.696	0.462	.002	27	view →
THCA	DFS	Tertile	All	0.961	0.866	.003	22	view →
SARC	OS	Quartile	All	0.990	0.764	<.001	22	view →
PAAD	DFS	Quartile	All	0.486	0.182	.005	16	view →
ACC	DFS	Quartile	II,III,IV	0.225	0.706	.004	13	view →
READ	DFS	Tertile	IV	0.889	0.295	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SEC11C–UVM (DFS)

Open the UVM breakdown →