SEC11C

Across TCGA patient cohorts, SEC11C mutation is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC11C-associated genes across cancer lineages are GYG1P2, MIR98, and NDUFA4P2. Each is linked with SEC11C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC11C-to-partner and partner-to-SEC11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYG1P2 grouped by SEC11C-low versus SEC11C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11C→partner) and Y-score (partner→SEC11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GYG1P2 →	+0.067	+3.622	<.001	.005	3	2
UCEC	MIR98 →	+0.362	+2.631	<.001	.007	3	1
SKCM	NDUFA4P2 →	+0.098	+3.622	.002	.005	3	1
SKCM	SYP-AS1 →	+0.082	+3.521	.008	.002	3	1
SKCM	RNU6-104P →	+0.345	+5.054	<.001	<.001	3	1
SKCM	MORC1-AS1 →	+0.049	+4.671	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

GYG1P2 by SEC11C expression — SKCM

Explore this box plot interactively →