SEC11C

Across TCGA patient cohorts, SEC11C mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC11C-associated genes across cancer lineages are JNK2, Ku80, and C-Raf. Each is linked with SEC11C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC11C-to-partner and partner-to-SEC11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SEC11C-low versus SEC11C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11C→partner) and Y-score (partner→SEC11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.306	+3.009	.003	.019	3	1
UCEC	Ku80 →	+0.268	+2.183	.030	.035	3	1
UCEC	C-Raf →	+0.262	+3.321	<.001	.010	3	1
UCEC	TFRC →	+0.912	+3.321	.001	.010	1	1
UCEC	4E-BP1 →	+0.466	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by SEC11C expression — UCEC

Explore this box plot interactively →