SEC11C

Across TCGA cell cohorts, SEC11C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,048 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEC11C-associated GO terms across cancer lineages are Endodermal cell differentiation, Cell-substrate adhesion, and Regulation of cell-substrate adhesion. Each is linked with SEC11C in more than 12 cancer types. Because this analysis shows association rather than direction, both SEC11C-to-partner and partner-to-SEC11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endodermal cell differentiation grouped by SEC11C-low versus SEC11C-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11C→partner) and Y-score (partner→SEC11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Endodermal cell differentiation →	-0.162	-2.509	.007	.001	3	13
BONE	Cell-substrate adhesion →	-0.142	-1.858	<.001	<.001	3	11
BONE	Regulation of cell-substrate adhesion →	-0.130	-1.936	<.001	<.001	3	10
BONE	Regulation of actin filament organization →	-0.077	-1.585	<.001	<.001	3	10
BONE	Regulation of focal adhesion assembly →	-0.175	-2.082	<.001	<.001	3	10
BONE	Regulation of cell-substrate junction assembly →	-0.175	-2.082	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,048 associations by consensus.

Endodermal cell differentiation by SEC11C expression — LUNG_SCLC

Explore this box plot interactively →