SEC11A

Across TCGA pan-cancer cohorts, SEC11A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC11A data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SEC11A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEC11A expression acts as an unfavorable survival marker.

UCS, CESC, and BLCA are the cancer types where SEC11A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.104	0.688	<.001	36	view →
CESC	OS	Median	All	0.047	0.875	<.001	24	view →
BLCA	OS	Median	III,IV	0.130	0.684	<.001	24	view →
ESCA	OS	Median	III,IV	0.102	0.574	<.001	15	view →
OV	DFS	Median	II,III,IV	0.204	0.541	.017	12	view →
BRCA	OS	Median	All	0.166	0.578	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC11A–UCS (OS)

Open the UCS breakdown →