SEC11A

Across TCGA pan-cancer cohorts, SEC11A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEC11A data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEC11A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC11A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where SEC11A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.922	0.667	.001	43	view →
CCRCC	DFS	Median	IV	0.131	0.861	.001	24	view →
LSCC	DFS	Tertile	II,III,IV	0.472	0.886	.007	13	view →
LUAD	DFS	Quartile	All	0.974	0.851	.016	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEC11A–HNSC (DFS)

Open the HNSC breakdown →