SEC11A

Across TCGA patient cohorts, SEC11A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC11A-associated genes across cancer lineages are eIF4G, FoxM1, and Heregulin. Each is linked with SEC11A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC11A-to-partner and partner-to-SEC11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by SEC11A-low versus SEC11A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11A→partner) and Y-score (partner→SEC11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.302	+2.459	.044	.020	3	1
UCEC	FoxM1 →	+0.295	+2.459	.018	.020	3	1
UCEC	Heregulin →	-0.120	-2.459	.044	.020	3	1
UCEC	Rab11 →	-0.177	-2.459	.011	.020	3	1
UCEC	Tuberin →	+0.355	+2.331	.006	.019	3	1
UCEC	ASNS →	+0.524	+3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4G by SEC11A expression — UCEC

Explore this box plot interactively →