SEC11A

Across TCGA cell cohorts, SEC11A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,950 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEC11A-associated GO terms across cancer lineages are Regulation of acute inflammatory response to antigenic stimulus, Negative regulation of acute inflammatory response to antigenic stimulus, and Positive regulation of protein exit from endoplasmic reticulum. Each is linked with SEC11A in more than 7 cancer types. Because this analysis shows association rather than direction, both SEC11A-to-partner and partner-to-SEC11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of acute inflammatory response to antigenic stimulus grouped by SEC11A-low versus SEC11A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11A→partner) and Y-score (partner→SEC11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of acute inflammatory response to antigenic stimulus →	+0.289	+0.723	<.001	<.001	3	8
BONE	Negative regulation of acute inflammatory response to antigenic stimulus →	+0.420	+0.892	<.001	<.001	3	8
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.161	+0.937	<.001	<.001	3	8
BONE	Carbohydrate derivative catabolic process →	+0.067	+0.740	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Isocitrate metabolic process →	+0.103	+0.413	<.001	.007	3	7
OESOPHAGUS	RNA import into nucleus →	+0.158	+0.493	<.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,950 associations by consensus.

Regulation of acute inflammatory response to antigenic stimulus by SEC11A expression — BONE

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