SDS

Across TCGA patient cohorts, SDS protein abundance is significantly associated with the RNA expression of many other genes, with 11,513 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDS-associated genes across cancer lineages are PKD2L1, APOE, and APOC1. Each is linked with SDS in more than 7 cancer types. Because this analysis shows association rather than direction, both SDS-to-partner and partner-to-SDS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SDS versus PKD2L1 in CCRCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDS→partner) and Y-score (partner→SDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PKD2L1 →	+0.809	+0.811	<.001	<.001	3	8
UCEC	APOE →	+1.590	+0.459	<.001	.001	3	7
UCEC	APOC1 →	+1.280	+0.519	<.001	<.001	3	7
CCRCC	HS3ST2 →	+1.333	+0.583	<.001	<.001	3	7
OV	SLC15A3 →	+0.701	+0.476	.006	.001	3	6
OV	CD86 →	+0.830	+0.401	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,513 associations by consensus.

SDS vs PKD2L1 — CCRCC

Explore this scatter interactively →