SDS

Across TCGA pan-cancer cohorts, SDS RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SDS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SDS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SDS is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where SDS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.888	<.001	12	view →
KIRP	Male	All	+3.098	<.001	11	view →
HNSC	Male	III,IV	+1.651	<.001	11	view →
STAD	Female	All	+2.994	<.001	10	view →
LUAD	All	III,IV	+1.516	<.001	8	view →
LIHC	All	II,III,IV	−3.061	<.001	7	view →
UCEC	All	III,IV	+2.211	<.001	6	view →
BRCA	All	III,IV	+2.028	<.001	6	view →
BLCA	All	IV	+1.952	.012	6	view →
CHOL	Male	All	−5.983	<.001	5	view →
KICH	All	All	+1.564	<.001	5	view →
LUSC	Female	All	+1.169	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SDS–KIRC

Open the KIRC breakdown →