SDS

Across TCGA patient cohorts, SDS mutation is significantly associated with the RNA expression of many other genes, with 2,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDS-associated genes across cancer lineages are AQP7P4, RPL17P12, and RNU6-1052P. Each is linked with SDS in more than 2 cancer types. Because this analysis shows association rather than direction, both SDS-to-partner and partner-to-SDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P4 grouped by SDS-low versus SDS-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDS→partner) and Y-score (partner→SDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AQP7P4 →	+0.081	+5.984	<.001	.002	3	3
SKCM	RPL17P12 →	+0.040	+4.328	<.001	.007	3	3
HNSC	RNU6-1052P →	+0.288	+7.954	<.001	.008	3	2
HNSC	RN7SL185P →	+0.134	+7.954	<.001	.008	3	2
UCEC	CISD3 →	+0.451	+2.823	.009	.001	3	2
UCEC	SNX3P1Y →	+0.080	+4.156	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

AQP7P4 by SDS expression — LUAD

Explore this box plot interactively →