SDS

Across TCGA cell cohorts, SDS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,031 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SDS-associated GO terms across cancer lineages are Lysosomal lumen acidification, Regulation of cytoplasmic pattern recognition receptor signaling pathway, and Negative regulation of autophagy. Each is linked with SDS in more than 10 cancer types. Because this analysis shows association rather than direction, both SDS-to-partner and partner-to-SDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by SDS-low versus SDS-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDS→partner) and Y-score (partner→SDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lysosomal lumen acidification →	+0.098	+0.344	<.001	<.001	3	11
LARGE_INTESTINE	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.060	+0.091	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.091	+0.155	<.001	<.001	3	9
CNS	Vacuolar acidification →	+0.101	+0.362	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.071	+0.122	<.001	<.001	3	8
STOMACH	Heart contraction →	-0.109	-0.147	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,031 associations by consensus.

Lysosomal lumen acidification by SDS expression — BLOOD_Leukemia

Explore this box plot interactively →