SDS

Across TCGA cell cohorts, SDS mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SDS-associated genes across cancer lineages are ADIPOQ, OR5P2, and ETDC. Each is linked with SDS in more than 1 cancer types. Because this analysis shows association rather than direction, both SDS-to-partner and partner-to-SDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by SDS-low versus SDS-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDS→partner) and Y-score (partner→SDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADIPOQ →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5P2 →	+0.018	+4.867	.001	.009	3	1
BLOOD_Lymphoma	ETDC →	+0.556	+5.209	<.001	.005	3	1
SKIN	KRTAP15-1 →	+0.021	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ADIPOQ by SDS expression — BLOOD_Lymphoma

Explore this box plot interactively →