SDR39U1

Across TCGA patient cohorts, SDR39U1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDR39U1-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and p38-MAPK. Each is linked with SDR39U1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDR39U1-to-partner and partner-to-SDR39U1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SDR39U1-low versus SDR39U1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDR39U1→partner) and Y-score (partner→SDR39U1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.195	-3.156	.005	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.560	-3.169	.007	.019	3	1
UCEC	p38-MAPK →	-0.180	-2.986	.018	.035	3	1
UCEC	p62 Lck ligand →	+0.311	+2.179	.040	.034	3	1
UCEC	PAI-1 →	+0.422	+2.321	.008	.034	3	1
UCEC	STAT3_pY705 →	-0.478	-3.311	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

mTOR_pS2448 by SDR39U1 expression — UCEC

Explore this box plot interactively →