SDR16C5

Across TCGA patient cohorts, SDR16C5 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDR16C5-associated genes across cancer lineages are Rab11, Rad50, and STAT3_pY705. Each is linked with SDR16C5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDR16C5-to-partner and partner-to-SDR16C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab11 grouped by SDR16C5-low versus SDR16C5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDR16C5→partner) and Y-score (partner→SDR16C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rab11 →	-0.145	-2.000	.030	.027	3	2
UCEC	Rad50 →	-0.248	-3.000	.034	.036	3	2
UCEC	STAT3_pY705 →	-0.591	-3.584	<.001	.002	3	2
SKCM	CDK1_pY15 →	+0.440	+2.237	<.001	.005	3	2
UCEC	EGFR →	-0.258	-3.169	<.001	.019	3	1
UCEC	JNK2 →	+0.218	+2.459	.023	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Rab11 by SDR16C5 expression — SKCM

Explore this box plot interactively →