SDR16C5

Across TCGA pan-cancer cohorts, SDR16C5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SDR16C5 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SDR16C5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SDR16C5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

KIRC, PAAD, and HNSC are the cancer types where SDR16C5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	IV	0.159	0.442	<.001	42	view →
PAAD	OS	Median	All	0.281	0.522	.002	35	view →
HNSC	DFS	Median	All	0.428	0.278	.004	30	view →
LUSC	DFS	Median	All	0.706	0.809	.002	21	view →
LUAD	DFS	Tertile	IV	0.890	0.373	.005	18	view →
SKCM	OS	Quartile	II,III,IV	0.299	0.457	.009	16	view →
SCLC	OS	Tertile	II,III,IV	0.298	0.679	.005	15	view →
LGG	DFS	Tertile	All	0.807	0.647	.014	14	view →
UCEC	DFS	Quartile	All	0.434	0.715	.011	14	view →
UVM	DFS	Tertile	II,III,IV	0.643	0.874	.027	13	view →
STAD	OS	Quartile	III,IV	0.264	0.612	.016	9	view →
MESO	OS	Quartile	All	0.152	0.367	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SDR16C5–KIRC (DFS)

Open the KIRC breakdown →