SDK2

Across TCGA patient cohorts, SDK2 mutation is significantly associated with the RNA expression of many other genes, with 6,912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDK2-associated genes across cancer lineages are RAD51C, SKA2, and GSR. Each is linked with SDK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SDK2-to-partner and partner-to-SDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51C grouped by SDK2-low versus SDK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK2→partner) and Y-score (partner→SDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51C →	+0.362	+1.347	<.001	<.001	3	6
UCEC	SKA2 →	+0.443	+2.754	<.001	<.001	3	6
UCEC	GSR →	+0.591	+1.232	<.001	<.001	3	5
UCEC	EZH2 →	+0.321	+1.410	.004	.003	3	5
UCEC	PARP2 →	+0.384	+1.232	<.001	<.001	3	5
UCEC	BRIP1 →	+0.400	+1.968	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,912 associations by consensus.

RAD51C by SDK2 expression — UCEC

Explore this box plot interactively →