SDK2

Across TCGA pan-cancer cohorts, SDK2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SDK2 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SDK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SDK2 expression acts as an unfavorable survival marker, although some lineages such as KICH and UCS show a favorable association.

UVM, ACC, and STAD are the cancer types where SDK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.415	0.804	<.001	96	view →
ACC	DFS	Median	All	0.271	0.634	<.001	55	view →
STAD	DFS	Tertile	II,III,IV	0.266	0.513	.003	52	view →
KICH	DFS	Tertile	All	1.000	0.662	.002	44	view →
UCS	DFS	Tertile	III,IV	0.608	0.129	.002	42	view →
UCEC	OS	Quartile	All	0.821	0.909	.014	40	view →
PAAD	OS	Tertile	All	0.571	0.358	.001	37	view →
LUSC	DFS	Tertile	III,IV	0.226	0.550	.003	24	view →
KIRP	OS	Median	IV	0.045	0.590	.025	15	view →
LIHC	OS	Median	II,III,IV	0.584	0.305	.009	14	view →
HNSC	DFS	Tertile	III,IV	0.330	0.264	.009	14	view →
THCA	OS	Quartile	II,III,IV	0.891	1.000	.022	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SDK2–UVM (OS)

Open the UVM breakdown →