SDK2

Across TCGA patient cohorts, SDK2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDK2-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and ATM. Each is linked with SDK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SDK2-to-partner and partner-to-SDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SDK2-low versus SDK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK2→partner) and Y-score (partner→SDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.892	+1.519	<.001	.014	3	4
STAD	4E-BP1 →	+0.305	+3.459	.023	.005	3	3
UCEC	ATM →	-0.371	-2.124	<.001	<.001	3	3
UCEC	eIF4E →	+0.111	+1.353	.034	.013	3	3
UCEC	Cyclin-B1 →	+0.382	+1.523	.006	.005	3	3
STAD	PCNA →	+0.310	+2.321	.017	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Caspase-7-cleavedD198 by SDK2 expression — COAD

Explore this box plot interactively →