SDK2

Across TCGA cell cohorts, SDK2 mutation is significantly associated with the RNA expression of many other genes, with 1,185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SDK2-associated genes across cancer lineages are IFT27, SLC32A1, and CUL9. Each is linked with SDK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDK2-to-partner and partner-to-SDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFT27 grouped by SDK2-low versus SDK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK2→partner) and Y-score (partner→SDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFT27 →	+0.715	+3.228	.007	.004	3	2
BLOOD_Leukemia	SLC32A1 →	+0.397	+2.619	<.001	<.001	3	2
BLOOD_Leukemia	CUL9 →	+0.552	+3.214	.009	.006	3	2
BLOOD_Leukemia	PPP1R3D →	-0.674	-3.459	<.001	.002	3	2
BLOOD_Leukemia	CCDC74A →	+1.479	+2.489	.002	.007	3	2
BLOOD_Leukemia	EOMES →	+0.469	+2.662	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,185 associations by consensus.

IFT27 by SDK2 expression — BLOOD_Leukemia

Explore this box plot interactively →