SDK1-AS1

Across TCGA pan-cancer cohorts, SDK1-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SDK1-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SDK1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SDK1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

SKCM, LUAD, and HNSC are the cancer types where SDK1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	II,III,IV	0.395	0.209	.001	66	view →
LUAD	OS	Tertile	All	0.471	0.264	.002	43	view →
HNSC	DFS	Quartile	IV	0.490	0.310	.006	40	view →
UCEC	DFS	Quartile	II,III,IV	0.624	0.769	.022	18	view →
THCA	DFS	Tertile	All	0.952	0.633	.009	16	view →
COAD	OS	Tertile	All	0.882	0.771	.010	16	view →
PRAD	DFS	Quartile	All	0.946	0.819	<.001	16	view →
MESO	DFS	Median	All	0.345	0.195	.015	15	view →
ACC	DFS	Tertile	IV	0.656	0.108	.010	15	view →
UVM	DFS	Quartile	All	0.803	0.505	.018	11	view →
KIRC	DFS	Quartile	IV	0.472	0.205	.013	10	view →
LGG	DFS	Median	All	0.675	0.829	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SDK1-AS1–SKCM (DFS)

Open the SKCM breakdown →