SDK1-AS1

Across TCGA pan-cancer cohorts, SDK1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SDK1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SDK1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SDK1-AS1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and BRCA are the cancer types where SDK1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDK1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−0.347	<.001	10	view →
BLCA	All	III,IV	−1.054	<.001	8	view →
BRCA	All	III,IV	−0.489	<.001	6	view →
THCA	All	All	+0.382	<.001	6	view →
HNSC	All	II,III,IV	+0.231	.004	6	view →
COAD	All	All	−0.235	<.001	5	view →
LUSC	All	All	+0.383	.001	4	view →
PRAD	All	All	+0.615	<.001	2	view →
STAD	Male	All	−0.177	.021	2	view →
LUAD	All	II,III,IV	−0.190	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SDK1-AS1–KICH

Open the KICH breakdown →