SDHC

Across TCGA cell cohorts, SDHC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,573 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SDHC-associated GO terms across cancer lineages are Tetrapyrrole metabolic process, Positive regulation of mRNA processing, and Mitochondrial transport. Each is linked with SDHC in more than 8 cancer types. Because this analysis shows association rather than direction, both SDHC-to-partner and partner-to-SDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tetrapyrrole metabolic process grouped by SDHC-low versus SDHC-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHC→partner) and Y-score (partner→SDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Tetrapyrrole metabolic process →	+0.099	+0.842	.005	.001	3	9
BLOOD_Leukemia	Positive regulation of mRNA processing →	+0.062	+0.476	.002	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Mitochondrial transport →	+0.103	+1.142	<.001	<.001	3	9
BONE	Forebrain radial glial cell differentiation →	+0.163	+0.723	.001	<.001	3	8
BONE	Glucoside transport →	+0.308	+1.048	<.001	<.001	3	8
BLOOD_Myeloma	Mitochondrial electron transport, NADH to ubiquinone →	+0.088	+1.115	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,573 associations by consensus.

Tetrapyrrole metabolic process by SDHC expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →