SDHB

Across TCGA patient cohorts, SDHB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDHB-associated genes across cancer lineages are FOXO3a_pS318_S321, Annexin-1, and STAT3_pY705. Each is linked with SDHB in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHB-to-partner and partner-to-SDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by SDHB-low versus SDHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHB→partner) and Y-score (partner→SDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.146	-2.990	.025	.036	3	1
UCEC	Annexin-1 →	+0.716	+2.827	.009	.035	3	1
UCEC	STAT3_pY705 →	-0.551	-3.321	<.001	.010	3	1
UCEC	Stathmin →	+0.184	+2.833	.010	.034	3	1
UCEC	Cyclin-B1 →	+0.679	+3.321	.021	.010	3	1
UCEC	EGFR_pY1068 →	-0.295	-3.321	.024	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FOXO3a_pS318_S321 by SDHB expression — UCEC

Explore this box plot interactively →