SDHB

Across TCGA pan-cancer cohorts, SDHB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SDHB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SDHB RNA is repressed in tumor relative to normal tissue. In most cancer types SDHB is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and COAD are the cancer types where SDHB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDHB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−0.913	<.001	9	view →
KIRC	Male	All	−0.686	<.001	9	view →
COAD	Male	All	−0.511	<.001	9	view →
BLCA	All	All	+0.370	<.001	8	view →
THCA	Male	III,IV	−0.357	<.001	8	view →
KICH	Female	II,III,IV	−1.211	<.001	7	view →
LIHC	All	II,III,IV	−0.353	.009	6	view →
CHOL	All	All	−0.941	<.001	5	view →
UCEC	All	III,IV	+0.376	.030	4	view →
LUSC	Male	All	+0.286	<.001	4	view →
HNSC	All	III,IV	+0.277	.004	3	view →
READ	All	All	−0.433	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SDHB–KIRP

Open the KIRP breakdown →