SDHAF4

Across TCGA pan-cancer cohorts, SDHAF4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SDHAF4 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SDHAF4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SDHAF4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THYM show a favorable association.

SCLC, SKCM, and THYM are the cancer types where SDHAF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	III,IV	0.274	0.814	<.001	61	view →
SKCM	OS	Quartile	II,III,IV	0.545	0.245	<.001	60	view →
THYM	DFS	Quartile	All	1.000	0.730	.001	50	view →
KIRC	OS	Tertile	All	0.736	0.586	.001	45	view →
OV	OS	Tertile	All	0.777	0.638	.001	42	view →
THCA	DFS	Quartile	All	0.783	0.937	.010	20	view →
CESC	OS	Median	IV	0.351	0.750	.020	18	view →
LIHC	DFS	Median	All	0.389	0.480	.012	16	view →
KIRP	DFS	Median	All	0.931	0.528	.001	10	view →
READ	DFS	Tertile	All	0.855	0.365	.022	6	view →
PAAD	DFS	Quartile	All	0.621	0.326	.025	6	view →
LUAD	DFS	Median	III,IV	0.514	0.738	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SDHAF4–SCLC (OS)

Open the SCLC breakdown →