SDHAF4

Across TCGA pan-cancer cohorts, SDHAF4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SDHAF4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SDHAF4 RNA is repressed in tumor relative to normal tissue. In most cancer types SDHAF4 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and COAD are the cancer types where SDHAF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDHAF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.462	<.001	10	view →
LIHC	All	III,IV	+0.732	<.001	9	view →
COAD	Female	II,III,IV	+0.867	<.001	8	view →
BRCA	All	III,IV	−0.693	<.001	6	view →
KIRC	Male	All	−0.395	<.001	6	view →
CHOL	Male	All	+1.381	<.001	3	view →
UCEC	All	IV	−1.665	.006	2	view →
LUSC	Male	III,IV	−1.299	.002	2	view →
LUAD	Female	II,III,IV	−0.470	.003	2	view →
HNSC	Male	IV	+0.452	.004	2	view →
ESCA	Female	All	+0.560	<.001	1	view →
READ	All	All	+0.526	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SDHAF4–KICH

Open the KICH breakdown →