SDCCAG8

Across TCGA patient cohorts, SDCCAG8 mutation is significantly associated with the RNA expression of many other genes, with 1,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDCCAG8-associated genes across cancer lineages are DEFB135, POLR2C, and RNU7-136P. Each is linked with SDCCAG8 in more than 3 cancer types. Because this analysis shows association rather than direction, both SDCCAG8-to-partner and partner-to-SDCCAG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB135 grouped by SDCCAG8-low versus SDCCAG8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDCCAG8→partner) and Y-score (partner→SDCCAG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DEFB135 →	+0.241	+2.589	.001	.009	3	4
UCEC	POLR2C →	+0.412	+2.256	<.001	.001	3	3
STAD	RNU7-136P →	+0.626	+4.879	<.001	.002	3	3
UCEC	RCCD1 →	+0.350	+1.960	.003	<.001	3	3
UCEC	SNORD126 →	+0.254	+1.766	.002	.007	3	3
SKCM	RNA5SP521 →	+0.205	+4.678	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,807 associations by consensus.

DEFB135 by SDCCAG8 expression — SKCM

Explore this box plot interactively →