SDCCAG8

Across TCGA pan-cancer cohorts, SDCCAG8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SDCCAG8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SDCCAG8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SDCCAG8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where SDCCAG8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDCCAG8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.004	<.001	10	view →
LIHC	Female	II,III,IV	+1.005	<.001	9	view →
THCA	All	II,III,IV	−0.562	<.001	9	view →
KICH	Female	II,III,IV	−1.744	<.001	8	view →
COAD	Male	All	+0.498	<.001	7	view →
LUSC	All	II,III,IV	−0.465	<.001	7	view →
STAD	All	All	+0.469	<.001	5	view →
BRCA	All	II,III,IV	+0.205	.003	4	view →
CHOL	Male	All	+2.396	<.001	3	view →
KIRP	Male	All	−0.355	.012	2	view →
LUAD	Female	III,IV	−0.465	.034	1	view →
BLCA	Female	III,IV	+0.435	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SDCCAG8–HNSC

Open the HNSC breakdown →