SDCCAG8

Across TCGA patient cohorts, SDCCAG8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDCCAG8-associated genes across cancer lineages are GAPDH, eEF2, and MEK1. Each is linked with SDCCAG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SDCCAG8-to-partner and partner-to-SDCCAG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SDCCAG8-low versus SDCCAG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDCCAG8→partner) and Y-score (partner→SDCCAG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.420	+3.459	.037	.005	3	3
UCEC	eEF2 →	+0.373	+2.459	.005	.018	3	2
UCEC	MEK1 →	+0.413	+2.700	.002	.005	3	2
UCEC	PTEN →	-0.326	-1.415	.028	.046	3	2
UCEC	Caspase-7-cleavedD198 →	+0.596	+1.604	.007	.041	3	2
UCEC	eIF4E →	+0.204	+3.472	.010	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GAPDH by SDCCAG8 expression — UCEC

Explore this box plot interactively →