SDCBP2

Across TCGA patient cohorts, SDCBP2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDCBP2-associated genes across cancer lineages are PDCD4, eIF4G, and ERK2. Each is linked with SDCBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDCBP2-to-partner and partner-to-SDCBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SDCBP2-low versus SDCBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDCBP2→partner) and Y-score (partner→SDCBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.548	-2.459	.015	.020	3	2
UCEC	eIF4G →	+0.325	+2.999	.030	.035	3	1
UCEC	ERK2 →	+0.290	+3.169	.001	.019	3	1
UCEC	GAPDH →	+0.688	+3.169	.007	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-2.999	.005	.035	3	1
UCEC	Notch1 →	+0.180	+2.820	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PDCD4 by SDCBP2 expression — UCEC

Explore this box plot interactively →