SCYL1

Across TCGA patient cohorts, SCYL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,139 significant associations in total. OV shows the largest number of these associations.

The most reproducible SCYL1-associated GO terms across cancer lineages are Positive regulation of mitotic sister chromatid segregation, Free ubiquitin chain polymerization, and Mitotic spindle elongation. Each is linked with SCYL1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SCYL1-to-partner and partner-to-SCYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic sister chromatid segregation grouped by SCYL1-low versus SCYL1-high in GBM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCYL1→partner) and Y-score (partner→SCYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	Positive regulation of mitotic sister chromatid segregation →	+0.093	+0.351	<.001	<.001	3	19
OV	Free ubiquitin chain polymerization →	+0.044	+0.406	<.001	<.001	3	18
MESO	Mitotic spindle elongation →	+0.074	+0.213	<.001	.002	3	18
ACC	Spindle midzone assembly →	+0.081	+0.779	<.001	<.001	3	17
ACC	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.061	+0.668	<.001	<.001	3	17
STAD	Maintenance of protein location in mitochondrion →	+0.052	+0.383	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,139 associations by consensus.

Positive regulation of mitotic sister chromatid segregation by SCYL1 expression — GBM

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