SCYL1

Across TCGA cell cohorts, SCYL1 mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCYL1-associated genes across cancer lineages are MUC5B, GALR3, and TMEM213. Each is linked with SCYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCYL1-to-partner and partner-to-SCYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC5B grouped by SCYL1-low versus SCYL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCYL1→partner) and Y-score (partner→SCYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MUC5B →	+2.694	+3.160	<.001	.006	3	2
LARGE_INTESTINE	GALR3 →	+0.081	+3.602	.003	.005	3	2
LARGE_INTESTINE	TMEM213 →	+0.219	+3.355	.003	.007	3	2
BLOOD_Leukemia	EBF2 →	+0.310	+3.999	<.001	.005	3	2
URINARY_TRACT	TRIM51 →	+0.025	+4.217	.003	.005	3	1
URINARY_TRACT	PRKACG →	+0.005	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

MUC5B by SCYL1 expression — LARGE_INTESTINE

Explore this box plot interactively →