SCUBE2

Across TCGA patient cohorts, SCUBE2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,231 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SCUBE2-associated genes across cancer lineages are CPE, FGF1, and NRIP3. Each is linked with SCUBE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCUBE2-to-partner and partner-to-SCUBE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCUBE2 versus CPE in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE2→partner) and Y-score (partner→SCUBE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CPE →	+1.483	+0.727	<.001	.002	3	4
BRCA	FGF1 →	+0.940	+0.891	<.001	<.001	3	4
BRCA	NRIP3 →	+1.133	+1.006	<.001	.001	3	4
BRCA	MAGED2 →	+1.246	+1.420	<.001	<.001	3	4
LSCC	CPQ →	+0.841	+1.046	<.001	<.001	3	4
HNSC	CPXM2 →	+1.658	+0.974	.008	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,231 associations by consensus.

SCUBE2 vs CPE — LSCC

Explore this scatter interactively →